Title of article
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors
Author/Authors
G. Ferretti، نويسنده , , M. Dukat، نويسنده , , M. Giannella*، نويسنده , , A. Piergentili، نويسنده , , M. Pigini، نويسنده , , W. Quaglia، نويسنده , , M. I. Damaj، نويسنده , , B. R. Martin، نويسنده , , R. A. Glennon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
733
To page
735
Abstract
A total of 20 substituted analogues of nicotine (1a) and homoazanicotine (3a) were examined in order to determine whether or not they might bind in a similar manner at α4β2 nicotinic acetylcholinergic (nACh) receptors. It was found that parallel structural changes in the two series resulted in parallel shifts in affinity. Evidence suggests that the two series are binding in a comparable fashion.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793004
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