Title of article
Novel synthesis of 2-Substituted 19-norvitamin D A-ring phosphine oxide from -glucose as a building block
Author/Authors
Masato Shimizu، نويسنده , , Yukiko Iwasaki، نويسنده , , Yoshinori Shibamoto، نويسنده , , Miki Sato، نويسنده , , H. F. DeLuca، نويسنده , , Sachiko Yamada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
809
To page
812
Abstract
19-Norvitamin D A-ring phosphine oxide 5 was synthesized by a new sequence mode starting from -glucose as a chiral template. Transformation of the pyranoside ring into the A-ring carbocycle was achieved by the Pd-catalyzed Ferrier rearrangement. The phosphine oxide 5 was obtained in an 18% overall yield by this novel cost-effective method.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793020
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