Title of article :
Interaction of binuclear xylylthiolato(2,2′,2″-terpyridine)platinum(II) complexes with DNA
Author/Authors :
Hiromasa Kurosaki، نويسنده , , Naoki Yamakawa، نويسنده , , Masamitsu Sumimoto، نويسنده , , Kana Kimura، نويسنده , , Masafumi Goto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The new binuclear platinum(II) complexes, (1,3-benzenedimethanethiolate-S)di(2,2′,2″-terpyridine)diplatinum(II) chloride tetrahydrate, 5, and (1,4-benzenedimethanethiolate-S)di(2,2′,2″-terpyridine)diplatinum(II) chloride tetrahydrate, 6, were synthesized in order to investigate the binding of platinum(II) complex with calf thymus DNA, which was examined by UV and CD spectroscopies. Complex 5 interacted strongly with DNA by intercalation compared to 6.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
