Title of article
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines
Author/Authors
Sarah Chackal، نويسنده , , Michael Facompré، نويسنده , , Raymond Houssin، نويسنده , , Jean-François Goossens، نويسنده , , Nicole Pommery، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Christian Bailly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
943
To page
946
Abstract
Several benzo[c]pyrido[2,3,4-kl]acridines bearing different substituents on the A and E rings were synthesized and evaluated for their capacity to bind to DNA and to inhibit DNA topoisomerases. Potent cytotoxic compounds were discovered but no strict correlation with their DNA binding affinity and effects on topoisomerases were observed. DNA is one but not the unique target of these compounds.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793050
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