Author/Authors :
Sarah Chackal، نويسنده , , Michael Facompré، نويسنده , , Raymond Houssin، نويسنده , , Jean-François Goossens، نويسنده , , Nicole Pommery، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Christian Bailly، نويسنده ,
Abstract :
Several benzo[c]pyrido[2,3,4-kl]acridines bearing different substituents on the A and E rings were synthesized and evaluated for their capacity to bind to DNA and to inhibit DNA topoisomerases. Potent cytotoxic compounds were discovered but no strict correlation with their DNA binding affinity and effects on topoisomerases were observed. DNA is one but not the unique target of these compounds.
