Title of article :
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Author/Authors :
Jeewoo Lee، نويسنده , , Sung Eun Kim، نويسنده , , Ji-Young Lee، نويسنده , , Su Yeon Kim ، نويسنده , , Sang Uk Kang، نويسنده , , Seung Hwan Seo، نويسنده , , Moon Woo Chun and، نويسنده , , Taehee Kang، نويسنده , , Soo Young Choi، نويسنده , , Hea Ok Kim، نويسنده ,
Abstract :
A series of sulfamate surrogates of methionyl and isoleucyl adenylate have been investigated as MetRS and IleRS inhibitors by modifications of the sulfamate linker and adenine moieties. The discovery of 2-iodo Ile-NHSO2-AMP (58) as a potent Escherichia coli IleRS inhibitor revealed that a significant hydrophobic interaction between the 2-substituent of Ile-NHSO2-AMP and the adenine binding site of IleRS provided its high potency to the enzyme.
