Title of article :
Glycine α-Ketoamides as HCV NS3 Protease Inhibitors
Author/Authors :
Wei Han، نويسنده , , Zilun Hu، نويسنده , , Xiangjun Jiang، نويسنده , , Zelda R. Wasserman، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Using a tetrapeptide-based α-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC50 of 0.060 μM
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
