Author/Authors :
Jason D. Speake، نويسنده , , Frank Navas III، نويسنده , , Michael J. Bishop، نويسنده , , Deanna T. Garrison، نويسنده , , Eric C. Bigham، نويسنده , , Stephen J. Hodson، نويسنده , , David L. Saussy Jr.، نويسنده , , Jim A. Liacos، نويسنده , , Paul E. Irving، نويسنده , , Bryan W. Sherman، نويسنده ,
Abstract :
The structure–activity relationship of 2′-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as α1 adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent α1A subtype selective agonists have been identified.
