Title of article
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3
Author/Authors
Scott H. Watterson، نويسنده , , T. G. Murali Dhar، نويسنده , , Shelley K. Ballentine، نويسنده , , Zhongqi Shen، نويسنده , , Joel C. Barrish، نويسنده , , Daniel Cheney، نويسنده , , Catherine A. Fleener، نويسنده , , Katherine A. Rouleau، نويسنده , , Robert Townsend، نويسنده , , Diane L. Hollenbaugh، نويسنده , , Edwin J. Iwanowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1273
To page
1276
Abstract
The development of a series of novel indole-based inhibitors of 5′-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure–activity relationships (SARs) derived from in vitro studies are outlined.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793121
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