Title of article :
Design and synthesis of S-(−)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist
Author/Authors :
Mar?a L. L?pez-Rodr?guez، نويسنده , , M José Morcillo، نويسنده , , Esther Fern?ndez، نويسنده , , Bellinda Benhamu، نويسنده , , Ignacio Tejada، نويسنده , , David Ayala، نويسنده , , Alma Viso، نويسنده , , Mireia Olivella، نويسنده , , Leonardo Pardo، نويسنده , , Mercedes Delgado، نويسنده , , Jorge Manzanares، نويسنده , , José A. Fuentes، نويسنده ,
Abstract :
Based on a computational model for 5-HT1AR-ligand interaction and QSAR studies, we have designed and synthesized a new series of arylpiperazines 2–8 which exhibit high 5-HT1AR affinity and selectivity over α1-adrenergic receptors. Among them, compound CSP-2503 (4) has been pharmacologically characterized as a 5-HT1AR agonist at somatodendritic and postsynaptic sites, endowed with anxiolytic properties.
