Author/Authors :
Chaowei Zhang، نويسنده , , Liang Jin، نويسنده , , Belinda Mondie، نويسنده , , Scott S. Mitchell، نويسنده , , Arlindo L. Castelhano، نويسنده , , Weizhong Cai، نويسنده , , Nils Bergenhem، نويسنده ,
Abstract :
Leporin B (1), a novel demethylated analogue of leporin A (2), was isolated from a taxonomically unidentified fungal strain as part of an effort to discover compounds with the ability to increase expression levels of the enzyme hexokinase II. The structure was determined by spectral methods, including 1D and 2D NMR, and HRMS. The relative stereochemistry was assigned by NOESY experiments and coupling constants.
