Title of article
High-throughput synthesis and optimization of thrombin inhibitors via urazole α-addition and Michael addition
Author/Authors
P. Douglas Boatman، نويسنده , , Jan Urban، نويسنده , , Minh Nguyen، نويسنده , , Maher Qabar، نويسنده , , Michael Kahn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
1445
To page
1449
Abstract
A novel α-addition of propiolates to urazoles followed by Michael addition of a variety of nucleophiles has been developed for rapid production and optimization of peptidomimetic drug leads. This technology has produced a number of highly potent and selective inhibitors of the serine protease, thrombin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793160
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