Author/Authors :
Michel Pérez، نويسنده , , Catherine Maraval، نويسنده , , Stephan Dumond، نويسنده , , Marie Lamothe، نويسنده , , Philippe Schambel، نويسنده , , Chantal Etiévant، نويسنده , , Bridget Hill، نويسنده ,
Abstract :
A novel series of compounds, derived from 4-amino-phenyl piperazine, has been designed to selectively inhibit farnesyl protein transferase (FPTase) as CAAX tetrapeptide analogues. Certain of these compounds were shown to possess low nanomolar inhibitory activity both against the isolated enzyme and in cultured cells.
