Author/Authors :
Bruce Tomczuk، نويسنده , , Tianbao Lu، نويسنده , , Richard M. Soll، نويسنده , , Cynthia Fedde، نويسنده , , Aihua Wang، نويسنده , , Larry Murphy، نويسنده , , Carl Crysler، نويسنده , , Malini Dasgupta، نويسنده , , Stephen Eisennagel، نويسنده , , John Spurlino، نويسنده , , Roger Bone، نويسنده ,
Abstract :
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.
