Title of article
Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors
Author/Authors
Bruce Tomczuk، نويسنده , , Tianbao Lu، نويسنده , , Richard M. Soll، نويسنده , , Cynthia Fedde، نويسنده , , Aihua Wang، نويسنده , , Larry Murphy، نويسنده , , Carl Crysler، نويسنده , , Malini Dasgupta، نويسنده , , Stephen Eisennagel، نويسنده , , John Spurlino، نويسنده , , Roger Bone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1495
To page
1498
Abstract
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793171
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