Author/Authors :
James R. Horton، نويسنده , , Julieanne M. Bostock، نويسنده , , Ian Chopra، نويسنده , , Lars Hesse، نويسنده , , Simon E. V. Phillips، نويسنده , , David J. Adams and ...[et al.]، نويسنده , , A. Peter Johnson، نويسنده , , Colin W. G. Fishwick، نويسنده ,
Abstract :
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.
