Title of article
Design and synthesis of spiro-cyclopentenyl and spiro-[ and ]-dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease
Author/Authors
David M. Andrews، نويسنده , , Paul S. Jones، نويسنده , , Gail Mills، نويسنده , , S. Lucy Hind، نويسنده , , Martin J. Slater، نويسنده , , Naimisha Trivedi، نويسنده , , Katrina J. Wareing، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1657
To page
1660
Abstract
Using the pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 2b, with a spiro-cyclobutyl P1 substituent and an isopropyl carbonyl substituent at the lactam nitrogen, has an IC50 value in the replicon cell-based assay of 3 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793205
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