Title of article
Identification of potent and broad-Spectrum antibiotics from SAR studies of a synthetic vancomycin analogue
Author/Authors
Kateri A. Ahrendt، نويسنده , , Jacob A. Olsen، نويسنده , , Masahiro Wakao، نويسنده , , Joaquim Trias، نويسنده , , Jonathan A. Ellman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1683
To page
1686
Abstract
Dimeric vancomycin analogues based on a lead compound identified from a library of synthetic analogues of vancomycin have up to 60-fold greater activity than vancomycin against vancomycin-resistant Enterococcus faecium (VRE, VanA phenotype). Simplified analogues have also been prepared and found to maintain activity against VRE and have broad-spectrum antibiotic activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793211
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