Author/Authors :
Piyasena Hewawasam*[1]، نويسنده , , Hao-Min Ding، نويسنده , , Nathan Chen، نويسنده , , H. Dalton King، نويسنده , , Jay Knipe، نويسنده , , Lorraine Pajor، نويسنده , , Astrid Ortiz، نويسنده , , Valentin K. Gribkoff، نويسنده , , John Starrett، نويسنده ,
Abstract :
A variety of water-soluble prodrugs of BMS-191011 was synthesized and evaluated for solution state stability and rate of conversion to BMS-191011 in rat and human plasma. The deoxycarnitine ester prodrug (11c) was selected for clinical evaluation based on its superior chemical stability, crystallinity and cleavage to BMS-191011 in human plasma.
