Title of article
New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA–PAI-1 complex formation
Author/Authors
Guillaume De Nanteuil، نويسنده , , Christine Lila-Ambroise، نويسنده , , Alain Rupin، نويسنده , , Marie-Odile Vallez، نويسنده , , Tony J. Verbeuren، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1705
To page
1708
Abstract
The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa–PAI-1 complex with submicromolar IC50. This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793216
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