Author/Authors :
Dane M. Springer، نويسنده , , Margaret E. Sorenson، نويسنده , , Stella Huang، نويسنده , , Timothy P. Connolly، نويسنده , , Joanne J. Bronson، نويسنده , , James A. Matson، نويسنده , , Ronald L. Hanson، نويسنده , , David B. Brzozowski، نويسنده , , Thomas L. LaPorte، نويسنده , , Ramesh N. Patel، نويسنده ,
Abstract :
A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.
