Title of article
4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists
Author/Authors
Bernd Büttelmann، نويسنده , , Alexander Alanine، نويسنده , , Anne Bourson، نويسنده , , Ramanjit Gill، نويسنده , , Marie-Paule Heitz، نويسنده , , Vincent Mutel، نويسنده , , Emmanuel Pinard، نويسنده , , Gerhard Trube، نويسنده , , René Wyler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1759
To page
1762
Abstract
A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs α1 and M1 receptors) and activity in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793229
Link To Document