Title of article :
A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
Author/Authors :
Shu-Wei Yang، نويسنده , , Alexei Buivich، نويسنده , , Tze-Ming Chan، نويسنده , , Michelle Smith، نويسنده , , Jean Lachowicz، نويسنده , , Shirley A. Pomponi، نويسنده , , Amy E. Wright، نويسنده , , Ronald Mierzwa، نويسنده , , Mahesh Patel، نويسنده , , Vincent Gullo، نويسنده , , Min Chu، نويسنده ,
Abstract :
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new sterol sulfate Sch 572423 (2). Compounds 1 and 2 were identified as P2Y12 inhibitors with IC50 of 0.48 and 2.2 μM, respectively. The general method of purification for the MFL library and the structure elucidation of compound 2 are described.
