Title of article
Non-Peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold
Author/Authors
Michael J. Breslin، نويسنده , , Mark E. Duggan، نويسنده , , Wasyl Halczenko، نويسنده , , Carmen Fernandez-Metzler، نويسنده , , Cecilia A. Hunt، نويسنده , , Chih-Tai Leu، نويسنده , , Kara M. Merkle، نويسنده , , Adel M. Naylor-Olsen، نويسنده , , Thomayant Prueksaritanont، نويسنده , , Gary Stump، نويسنده , , Audrey Wallace، نويسنده , , Sevgi B. Rodan، نويسنده , , John H. Hutchinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1809
To page
1812
Abstract
Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared. Modification of the β-alanine 3-substituent produced compounds that are potent and selective αvβ3 antagonists and exhibit a range of physicochemical properties.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793240
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