Author/Authors :
Minoru Taguchi، نويسنده , , Kikuo Sugimoto، نويسنده , , Ken-ichi Goda، نويسنده , , Tomoko Akama، نويسنده , , Kyoko Yamamoto، نويسنده , , Taizo Suzuki، نويسنده , , Yasumitsu Tomishima، نويسنده , , Mariko Nishiguchi، نويسنده , , Koshi Arai، نويسنده , , Kenzo Takahashi، نويسنده , , Takeo Kobori، نويسنده ,
Abstract :
To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showed inhibitory activity with an IC50 value of μM on neutral sphingomyelinase in rat brain microsomes. Compound 8i showed a selective neutral sphingomyelinase inhibitory activity.
