Title of article
Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Author/Authors
Masaaki Sawa، نويسنده , , Kiriko Kurokawa، نويسنده , , Yoshimasa Inoue، نويسنده , , Hirosato Kondo، نويسنده , , Kohichiro Yoshino، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2021
To page
2024
Abstract
A novel series of phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793288
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