Title of article
Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore
Author/Authors
Michael D. Urbaniak، نويسنده , , Lisa M. Frost، نويسنده , , John P. Bingham، نويسنده , , Lloyd R. Kelland، نويسنده , , John A. Hartley، نويسنده , , Derek N. Woolfson، نويسنده , , Stephen Caddick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
2025
To page
2027
Abstract
Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793289
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