Author/Authors :
Michael D. Urbaniak، نويسنده , , Lisa M. Frost، نويسنده , , John P. Bingham، نويسنده , , Lloyd R. Kelland، نويسنده , , John A. Hartley، نويسنده , , Derek N. Woolfson، نويسنده , , Stephen Caddick، نويسنده ,
Abstract :
Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.
