• Title of article

    -Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety

  • Author/Authors

    Udo E. W. Lange، نويسنده , , Dorit Baucke، نويسنده , , Wilfried Hornberger، نويسنده , , Helmut Mack، نويسنده , , Werner Seitz، نويسنده , , H. Wolfgang H?ffken، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2003
  • Pages
    5
  • From page
    2029
  • To page
    2033
  • Abstract
    Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin–inhibitor complex X-ray structures.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2003
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    793290

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793290