Author/Authors :
Chad E. Stephens، نويسنده , , Reto Brun، نويسنده , , Manar M. Salem، نويسنده , , Karl A. Werbovetz، نويسنده , , Farial Tanious، نويسنده , , W. David Wilson، نويسنده , , David W. Boykin، نويسنده ,
Abstract :
The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 μmol versus T. cruzi and five gave similar values versus L. donovani.
