Title of article :
Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators
Author/Authors :
Lin Zhi، نويسنده , , Christopher M. Tegley، نويسنده , , Barbara Pio، نويسنده , , James P. Edwards، نويسنده , , Todd K. Jones، نويسنده , , Keith B. Marschke، نويسنده , , Dale E. Mais، نويسنده , , Boris Risek، نويسنده , , William T. Schrader، نويسنده ,
Abstract :
A series of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives were synthesized and tested in biological assays to evaluate scope and limitations of the nonsteroidal SPRM pharmacophore (3). A number of orally available highly potent nonsteroidal modulators were identified by modification of the substituents at 5-methylidene position.
