Title of article :
2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists: further characterization of 3,5-Dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-Trimethyl-propyl) ester and structure–Activity relationships
Author/Authors :
Fabrizio Micheli، نويسنده , , Romano Di Fabio، نويسنده , , Fabio Bordi، نويسنده , , Palmina Cavallini، نويسنده , , Paolo Cavanni، نويسنده , , Daniele Donati، نويسنده , , Stefania Faedo، نويسنده , , Micaela Maffeis، نويسنده , , Fabio Maria Sabbatini، نويسنده , , Giorgio Tarzia، نويسنده , , Maria Elvira Tranquillini، نويسنده ,
Abstract :
Following the disclosure of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester [3,5-dimethyl PPP] as a potent and selective mGluR1 non-competitive antagonist, we report here further in vivo characterization of this important tool and disclose the investigation of the C-5 position, which led to very potent compounds.
