Title of article
2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists: further characterization of 3,5-Dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-Trimethyl-propyl) ester and structure–Activity relationships
Author/Authors
Fabrizio Micheli، نويسنده , , Romano Di Fabio، نويسنده , , Fabio Bordi، نويسنده , , Palmina Cavallini، نويسنده , , Paolo Cavanni، نويسنده , , Daniele Donati، نويسنده , , Stefania Faedo، نويسنده , , Micaela Maffeis، نويسنده , , Fabio Maria Sabbatini، نويسنده , , Giorgio Tarzia، نويسنده , , Maria Elvira Tranquillini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
2113
To page
2118
Abstract
Following the disclosure of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester [3,5-dimethyl PPP] as a potent and selective mGluR1 non-competitive antagonist, we report here further in vivo characterization of this important tool and disclose the investigation of the C-5 position, which led to very potent compounds.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793308
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