Title of article
Bivalent biogenic amine reuptake inhibitors
Author/Authors
Keith Fandrick، نويسنده , , Xianqi Feng، نويسنده , , Aaron Janowsky، نويسنده , , Robert Johnson، نويسنده , , John R. Cashman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2151
To page
2154
Abstract
A series of aryltropane-based bivalent ligands was prepared and investigated for binding potency and for their ability to inhibit reuptake of human dopamine, serotonin and norepinephrine transporters. The bivalent ligand 4, comprised of linking an aryltropane by an octamethylene spacer showed high efficacy for the human dopamine transporter and had a discrimination ratio of 130.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793316
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