Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human β3 adrenergic receptor (β3-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent β3-AR agonists and have good selectivity against β1- and β2-AR.