Title of article :
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors
Author/Authors :
P. N. Praveen Rao، نويسنده , , Mohsen Amini، نويسنده , , Thomas L Poulos and CS Raman and Huiying Li، نويسنده , , Amgad G. Habeeb، نويسنده , , Edward E. Knaus، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
A novel class of 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones possessing a central six-membered lactone (pyran-2-one) ring system, in conjunction with C-6 alkyl (Me, Et or i-Pr), alkoxy (OMe, OEt or O-i-Pr), and alkylthio (SMe, SEt or S-i-Pr) substituents, were designed for evaluation as selective COX-2 inhibitors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
