Title of article
Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors
Author/Authors
John Finn، نويسنده , , Karen Mattia، نويسنده , , Mike Morytko، نويسنده , , Siya Ram، نويسنده , , Yingfei Yang، نويسنده , , Ximao Wu، نويسنده , , Elsa Mak، نويسنده , , Paul Gallant، نويسنده , , Dennis Keith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2231
To page
2234
Abstract
Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793332
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