Author/Authors :
John Finn، نويسنده , , Karen Mattia، نويسنده , , Mike Morytko، نويسنده , , Siya Ram، نويسنده , , Yingfei Yang، نويسنده , , Ximao Wu، نويسنده , , Elsa Mak، نويسنده , , Paul Gallant، نويسنده , , Dennis Keith، نويسنده ,
Abstract :
Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.
