Title of article
Pyrazole-O-glucosides as novel Na+-glucose cotransporter (SGLT) inhibitors
Author/Authors
Koji Ohsumi، نويسنده , , Hiroyuki Matsueda، نويسنده , , Toshihiro Hatanaka، نويسنده , , Ryusuke Hirama، نويسنده , , Takashi Umemura، نويسنده , , Akiko Oonuki، نويسنده , , Nozomu Ishida، نويسنده , , Yoko Kageyama، نويسنده , , Katsumi Maezono، نويسنده , , Nobuo Kondo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2269
To page
2272
Abstract
O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [14C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793339
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