Author/Authors :
Koji Ohsumi، نويسنده , , Hiroyuki Matsueda، نويسنده , , Toshihiro Hatanaka، نويسنده , , Ryusuke Hirama، نويسنده , , Takashi Umemura، نويسنده , , Akiko Oonuki، نويسنده , , Nozomu Ishida، نويسنده , , Yoko Kageyama، نويسنده , , Katsumi Maezono، نويسنده , , Nobuo Kondo، نويسنده ,
Abstract :
O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [14C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
