Author/Authors :
Dina Manetti، نويسنده , , Elisabetta Martini، نويسنده , , Carla Ghelardini، نويسنده , , Silvia Dei، نويسنده , , Nicoletta Galeotti، نويسنده , , Luca Guandalini، نويسنده , , Maria Novella Romanelli، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده , , Alessandro Bartolini، نويسنده , , Fulvio Gualtieri، نويسنده ,
Abstract :
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimerʹs disease.
