Title of article
An Evaluation of a C-Glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist
Author/Authors
Bryan K. Sorensen، نويسنده , , J. T. Link، نويسنده , , Thomas von Geldern، نويسنده , , Maurice Emery، نويسنده , , Jiahong Wang، نويسنده , , Bach Hickman، نويسنده , , Marlena Grynfarb، نويسنده , , Annika Goos-Nilsson، نويسنده , , Sherry Carroll، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2307
To page
2310
Abstract
A β-C-glucuronide conjugate of the glucocorticoid receptor antagonist, Mifepristone 1, was prepared which maintained binding affinity, had modest in vitro activity, and was metabolically more stable than the parent. Pharmacokinetic studies suggest that the conjugate is recognized by the liver like O-glucuronides and may undergo a portion of the enterohepatic recirculation loop.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793345
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