Title of article
L-Serine and glycine based ceramide analogues as transdermal permeation enhancers: polar head size and hydrogen bonding
Author/Authors
Kate ina V?vrov?، نويسنده , , Alexandr Hrab?lek، نويسنده , , Pavel Dole al، نويسنده , , Tom? Holas، نويسنده , , Jarmila Zbytovsk?، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
2351
To page
2353
Abstract
Novel transdermal permeation enhancers related to stratum corneum ceramides were investigated. The synthesis of a series of simple compounds based on two selected amino acids, -serine and glycine, and their enhancement activities are reported. Glycine derivative 3 enhanced the permeation of theophylline through human skin in vitro 12.5±0.5 times. The relationships between properties of the polar head of the compounds and their activity are discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793354
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