Title of article
Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2
Author/Authors
Kumiko Takeuchi، نويسنده , , Todd J. Kohn، نويسنده , , Nicholas A. Honigschmidt، نويسنده , , Vincent P. Rocco، نويسنده , , Patrick G. Spinazze، نويسنده , , Daniel J. Koch، نويسنده , , Steven T. Atkinson، نويسنده , , Larry W. Hertel، نويسنده , , Albert L. Lehninger, David L. Nelson, Michael M. Cox، نويسنده , , D. Bradley Wainscott، نويسنده , , Laura J. Ahmad، نويسنده , , Janice Shaw، نويسنده , , Penny G. Threlkeld، نويسنده , , David T. Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
2393
To page
2397
Abstract
Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an α-Me group in the piperidine ring with its specific stereochemistry enhanced binding affinity at the 5-HT reuptake site and in vitro 5-HT1A antagonist functional activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793364
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