Author/Authors :
Carole Anastasi، نويسنده , , Patrick Vlieghe، نويسنده , , Olivier Hantz، نويسنده , , Olivier Schorr، نويسنده , , Christophe Pannecouque، نويسنده , , Myriam Witvrouw، نويسنده , , Erik De Clercq، نويسنده , , Pascal Clayette، نويسنده , , Nathalie Dereuddre-Bosquet، نويسنده , , Dominique Dormont، نويسنده , , Françoise Gondois-Rey، نويسنده , , Ivan Hirsch، نويسنده , , Jean-Louis Kraus، نويسنده ,
Abstract :
In contrast to 5′-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15–21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.
