Title of article
Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR
Author/Authors
Mark T. Bilodeau، نويسنده , , April M. Cunningham، نويسنده , , Timothy J. Koester، نويسنده , , Patrice A. Ciecko، نويسنده , , Kathleen E. Coll، نويسنده , , William R. Huckle، نويسنده , , Randall W. Hungate، نويسنده , , Richard L. Kendall، نويسنده , , Rosemary C. McFall، نويسنده , , Xianzhi Mao، نويسنده , , Ruth Z. Rutledge، نويسنده , , Kenneth A. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2485
To page
2488
Abstract
1,5-Diarylbenzimidazoles have been identified as potent inhibitors of KDR kinase activity. The series was developed with a goal of finding compounds with optimal drug-like properties. This communication describes structural modifications in the series that enhance solubility, lower protein binding, and provide compounds with excellent potency and pharmacokinetic profiles.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793382
Link To Document