Title of article
Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics
Author/Authors
Phaik-Eng Sum، نويسنده , , David How، نويسنده , , Nancy Torres، نويسنده , , Howard Newman، نويسنده , , Peter J. Petersen، نويسنده , , Tarek S. Mansour، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2607
To page
2610
Abstract
A series of benzoxazole derivatives of the mannopeptimycin glycopeptide antibiotics was synthesized via a novel benzoxazole formation reaction by treating aminophenol of mannopeptimycin-β with an aldehyde and DDQ in DMF. Some of these derivatives (e.g., 5b, 5d, 5m, and 7b) showed good activity against Gram-(+) bacteria when compared to the parent compound mannopeptimycin-β.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793410
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