Author/Authors :
Stephen J. Davies، نويسنده , , Andrew P. Ayscough، نويسنده , , R. Paul Beckett، نويسنده , , Ryan A. Bragg، نويسنده , , John M. Clements، نويسنده , , Sheila Doel، نويسنده , , Christine Grew، نويسنده , , Steven B. Launchbury، نويسنده , , Gemma M. Perkins، نويسنده , , Lisa M. Pratt، نويسنده , , Helen K. Smith، نويسنده , , Zoe M. Spavold، نويسنده , , S. Wayne Thomas، نويسنده , , Richard S. Todd، نويسنده , , Mark Whittaker، نويسنده ,
Abstract :
Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to the methylene spacer and the P1′ side chain. Enzyme inhibition and antibacterial activity data revealed that the optimum distance between the N-formyl hydroxylamine metal binding group and the P1′ side chain is one unsubstituted methylene unit. Additionally, lipophilic P1′ side chains that closely mimic the methionine residue in the substrate provided compounds with the best microbiological profile.
