Title of article
Structure–activity relationships of azasugar-based MMP/ADAM inhibitors
Author/Authors
Hideki Moriyama، نويسنده , , Takahiro Tsukida، نويسنده , , Yoshimasa Inoue، نويسنده , , Hirosato Kondo، نويسنده , , Kohichiro Yoshino، نويسنده , , Shin-ichiro Nishimura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2737
To page
2740
Abstract
In order to investigate structure–activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793437
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