Title of article
5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
Author/Authors
Ranjit C. Desai، نويسنده , , Wei Han، نويسنده , , Edward J. Metzger، نويسنده , , Jeffrey P. Bergman، نويسنده , , Dominick F. Gratale، نويسنده , , Karen L. MacNaul، نويسنده , , Joel P. Berger، نويسنده , , Thomas W. Doebber، نويسنده , , Kwan-Leung Chan MD FRCPC، نويسنده , , David E. Moller، نويسنده , , James V. Heck، نويسنده , , Soumya P. Sahoo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2795
To page
2798
Abstract
A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARα/γ agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793450
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