Title of article
Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics
Author/Authors
Phaik-Eng Sum، نويسنده , , David How، نويسنده , , Nancy Torres، نويسنده , , Peter J. Petersen، نويسنده , , Joseph Ashcroft، نويسنده , , Edmund I. Graziani، نويسنده , , Frank E. Koehn، نويسنده , , Tarek S. Mansour، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2805
To page
2808
Abstract
A number of 6-O-ether and 4-O-ether derivatives of mannopeptimycin-α with different steric bulk and lipophilicity were synthesized for structure–activity relationship study. Novel iodo and bromo mannopeptimycin-α were also prepared. These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793452
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