Author/Authors :
Phaik-Eng Sum، نويسنده , , David How، نويسنده , , Nancy Torres، نويسنده , , Peter J. Petersen، نويسنده , , Joseph Ashcroft، نويسنده , , Edmund I. Graziani، نويسنده , , Frank E. Koehn، نويسنده , , Tarek S. Mansour، نويسنده ,
Abstract :
A number of 6-O-ether and 4-O-ether derivatives of mannopeptimycin-α with different steric bulk and lipophilicity were synthesized for structure–activity relationship study. Novel iodo and bromo mannopeptimycin-α were also prepared. These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP.
