Title of article
Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity
Author/Authors
Gunther Bal، نويسنده , , Pieter Van der Veken، نويسنده , , Dimitri Antonov، نويسنده , , Anne-Marie Lambeir، نويسنده , , Philippe Grellier، نويسنده , , Simon L. Croft، نويسنده , , Koen Augustyns، نويسنده , , Achiel Haemers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2875
To page
2878
Abstract
Prolylprolylisoxazoles and prolylprolylisoxazolines were synthesized through a 1,3-dipolar cycloaddition reaction. These compounds are potent inhibitors of human and trypanosomal prolyloligopeptidase. They were shown to inhibit Trypanosoma cruzi and Trypanosoma b. brucei in in vitro systems with ED50ʹs in the lower μM range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793466
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