Title of article
Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease
Author/Authors
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Pradip R. Das، نويسنده , , Nancy Butkiewicz، نويسنده , , Gladys Arreaza، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2925
To page
2928
Abstract
The 70% aq methanolic extract of the Peruvian plant Stylogne cauliflora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease. The structure of 1 and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC50 of 0.3 μM, while compound 2 showed an IC50 of 0.8 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793478
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