Title of article
Discovery and evaluation of 3-(5-Thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors
Author/Authors
Mark E. Fraley، نويسنده , , Kenneth L. Arrington، نويسنده , , Scott R. Hambaugh، نويسنده , , William F. Hoffman، نويسنده , , April M. Cunningham، نويسنده , , Mary Beth Young، نويسنده , , Randall W. Hungate، نويسنده , , Andrew J. Tebben، نويسنده , , Ruth Z. Rutledge، نويسنده , , Richard L. Kendall، نويسنده , , William R. Huckle، نويسنده , , Rosemary C. McFall، نويسنده , , Kathleen E. Coll، نويسنده , , Kenneth A. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2973
To page
2976
Abstract
We have discovered 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as potent inhibitors of KDR kinase activity. This communication details the evolution of this novel class from a potent screening lead of vastly different structure with an emphasis on structural modifications that retained activity and provided improvements in key physical properties. The synthesis and in-depth evaluation of these inhibitors are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793489
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