Title of article
Topological designing of 4-piperazinylquinazolines as antagonists of PDGFR tyrosine kinase family
Author/Authors
Keshav C. Mathur and Padmakar V. Khadikar، نويسنده , , Anjali Shrivastava، نويسنده , , Vijay K. Agrawal، نويسنده , , Shachi Srivastava، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3009
To page
3014
Abstract
Topological designing of a series of 4-piperazinylquinazolines as antagonists of platelet-derived growth factor receptor (PDGFR) tyrosine kinase family has been reported using a series of distance-based topological indices. Regression analysis of the data, using maximum R2 method indicated that inhibitory activity, pIC50 (μm), in cellular PGDFR phosphorylation assay can be modelled excellently in multi-parametric model. The results are discussed critically using cross-validated parameters.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793498
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