Title of article
Liquid-phase synthesis of a pegylated adenosine–oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase
Author/Authors
Kaido Viht، نويسنده , , K?rt Padari، نويسنده , , Gerda Raidaru، نويسنده , , Juhan Subbi، نويسنده , , Indrek Tammiste، نويسنده , , Margus Pooga، نويسنده , , Asko Uri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
3035
To page
3039
Abstract
An adenosine–oligoarginine conjugate (ARC) was assembled in a stepwise manner on a poly(ethylene glycol) carrier. The pegylated conjugate inhibited cAMP-dependent protein kinase with IC50=460 nM and the cellular uptake of its BODIPY FL derivative was demonstrated and compared to that of free ARC with fluorescence microscopy.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793503
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